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Log in to DirectAdmin.
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Navigate to Email Manager > Autoresponders.
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Click Create New Autoresponder.
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Fill out the fields:Email address (e.g., info@yourdomain.com).Subject of the auto-reply (e.g., "Out of Office").Message body.
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Email address (e.g., info@yourdomain.com).
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Subject of the auto-reply (e.g., "Out of Office").
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Message body.
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Set start and end dates if needed.
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Click Create.